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螺旋藻中的肽類分子或具有明顯的降血壓效應
更新日期: 2019-01-28 作者: Carrizzo A等 文章來源:Hypertension
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近日,一項刊登在國際雜志Hypertension(《高血壓》)上的研究報告中,來自羅馬大學等機構的科學家們通過研究表示,從螺旋藻中提取出的一種肽類或能通過擴張血管來抵禦高血壓,相關研究結果有望幫助研究人員後期開發出治療高血壓的新型療法。

如今,螺旋藻因具有多種有益效應而被越來越多的人認爲是超級食物,但目前研究人員並不清楚螺旋藻在機體中的作用機制,螺旋藻的學名爲鈍頂節旋藻(Arthrospira platensis),其是一種能進行光合作用的藍細菌,有時候其被歸類爲藍藻,而且被認爲是阿茲特克人(Aztecs)的食物。

這項研究中,研究者發現,一種來自螺旋藻中的提取物或能通過擴張血管來有效中和動脈高血壓。研究人員通過研究從螺旋藻中分離出了一種肽類(由氨基酸組成的特殊分子),當在實驗室中對離體的動脈和動物模型進行研究後他們發現,這種肽類能夠擴張動脈血管,從而産生抗高血壓的效應。

研究者Albino Carrizzo表示,我們首先模擬螺旋藻提取物在機體中的消化過程,換句話說,我們能夠再現攝入這種肽類物質後人類機體腸道所發生的改變,這樣研究人員就能夠分離出被機體所吸收的肽類分子。研究人員首先鑒別出了一種名爲SP6的肽類分子,當在實驗室中將SP6給予離體的血管後,該分子就能産生一種血管舒張的效應,而這就是一種潛在的抗高血壓的效應,隨後研究者將SP6給予高血壓動物模型,結果發現,SP6能夠産生一種降血壓的反應。

研究者指出,高血壓患者通常會在通過一氧化氮調節血管內壁反應的自然過程中存在缺陷,而我們從螺旋藻中分離出的肽類分子則能夠發揮一種積極性的作用,後期研究人員還需要進行更爲深入的研究來闡明SP6肽類分子的具體作用機制,研究者認爲,SP6或許能作爲常見藥物的一種天然佐劑來幫助改善高血壓患者的血管內皮功能,從而有效控制患者的高血壓。(來源:生物谷Bioon.com

 

Novel Potent Decameric Peptide of Spirulina platensis Reduces Blood Pressure Levels Through a PI3K/AKT/eNOS-Dependent Mechanism

 

Abstract  Considered as a superfood of the future, Spirulina platensis matrix has been extensively used because of its beneficial effect on the management of cardiovascular diseases. However, its nutraceutical properties, bioactive compounds, and molecular mechanisms are unknown. Here, we demonstrate that S platensis matrix processed in vitro by simulated gastrointestinal digestion induces direct endothelial nitric oxide (NO)-mediated vasorelaxation of resistance vessels in mice. To gain insight into the bioactive compounds responsible for this effect, we used a complex multistep peptidomic approach to fractionate the crude digest: of the 5 peptide fractions identified (A-E), only fraction E evoked vasorelaxation. High-resolution mass spectrometry-based screening revealed in E the presence of 4 main peptides (SP3-SP6 [spirulina peptides]), of which only SP6 (GIVAGDVTPI) exerted direct endothelium-dependent vasodilation of ex vivo vessels, an effect occurring via a PI3K (phosphoinositide-3-kinase)/AKT (serine/threonine kinase Akt) pathway converging on NO release. In vivo, administration of SP6 evoked a significant hemodynamic effect, reducing blood pressure, an action absent in eNOS (endothelial NO synthase)-de?cient mice. Of note, although lower doses of SP6 had no hemodynamic effects, it still enhanced endothelial NO vasorelaxation. Finally, in an experimental model of arterial hypertension, SP6 exerted an antihypertensive effect, improving endothelial vasorelaxation associated with enhanced serum nitrite levels. Based on our results, this novel decameric peptide may extend the possible fields of application for spirulina-derived peptides and could be developed into a promising nonpharmacological approach for the containment of pathologies associated with vascular NO misregulation.

 

原文鏈接:https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.11801


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